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[80] [82] Animal-derived food sources with a high concentration of vitamin B 12 include liver and other organ meats from lamb, veal, beef, and turkey

Beyond ATP depletion, other mechanisms likely contribute to the pathogenesis of LHON, elucidating its devastating clinical manifestation (Fig

Long H, Zhang S, Zeng S, Tong Y, Liu J, Liu C, et al

Additionally, Ganoderma lucidum extract has been reported to neutralize free radicals and reduce oxidative stress in the liver, with its triterpenoids and polysaccharides providing protection against CCl 4 -induced liver damage with minimal toxicity (14)

Moreover, previous studies have shown silymarin and silybin anti-angiogenic activity in human umbilical vein endothelial cells (HUVEC) dose-dependently by mechanism of decreasing of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) secretion (1,6)